Senior Research Scientist -Analytical Biochemistry

  • Company:
    CSL Behring
  • Location:
  • Salary:
    negotiable / month
  • Job type:
  • Posted:
    17 hours ago
  • Category:

Designs and implements business processes to enable product research and development portfolio prioritization, resource allocation, and risk management. Designs related integrated process and product team activities and directs technical and operational activities to ensure vertical and horizontal integration. Provides product portfolio analyses and reports to management committees for support of decision-making. Leads teams in strategy efforts, lifecycle management planning, and assessments of probability-of-success. Develops systems to support dynamic portfolio management. Serves a key role in portfolio evaluation process. Drives initiatives across functions, research and development units to create fully integrated strategies. Monitors and reports on portfolio status and proactively addresses and resolves issues.

**The Opportunity**

CSL Research is recruiting for a Senior Research Scientist – Analytical Chemist to join the Analytical Biochemistry group at the Bio21 Institute Parkville site. In this role, you will plan and conduct mass spectrometry-based studies supporting protein and lipoproteins biomarker analysis, structural characterisation, identification and quantification of product-related variants and impurities, comparability assessment and manufacturing development support. As such, this will require you to be a technical expert in the development, implementation and maintenance of key mass spectrometry-based analytical methods for protein characterisation and MOA studies. Your extensive knowledge in mass spectrometric techniques in combination with a wide variety of separation methods, for detailed characterisation of complex modified proteins as well as extensions to correlation with protein biomarker analysis will be an asset. If you are a proactive person having excellent attention to detail and want to be part of a growing organisation this could be your next long term role working in the heart of Melbourne.

**The Role**

Reporting to the Director of Analytical Biochemistry, your responsibilities include:

+ Develop MS based techniques for structural and functional characterisation of recombinant proteins

+ Develop MS based lipoproteomics discovery and validation platforms for MOA studies in a complex clinical setting.

+ Identify post-translational modifications and their associated heterogeneities with particular emphasis on those affecting structure and function

+ Perform general mass spectrometry tasks as per requirements

+ Maintain current awareness of key scientific/technical strategies and innovative technological developments in mass spectrometry

+ Lead and oversee experimental work in areas of direct responsibility as assigned by the Director of Analytical Biochemistry

+ Present results from both independent and collaborative laboratory work to internal and external collaborators as needed to facilitate smooth progress of CSL R&D projects

**To be successful**

+ PhD in biochemistry, chemistry, or a related field

+ At least 10 years of experience working in the relevant protein mass spectrometry field, specifically in the areas of protein characterisation and biomarker analysis.

+ Demonstrated experience in Analytical Chemistry with strong background in protein characterisation using various mass spectrometry based techniques

+ Significant and extensive expertise in operating and maintaining mass spectrometry instrumentation, particularly as applied to protein, peptide and glycan analysis (e.g. ESI-MS/MS, MALDI-MS/MS, good knowledge of qTOF’s, QqQ and Orbitrap instruments)

+ Demonstrated experience in multidimensional chromatography, 1- and 2-D gel electrophoresis and combination of separation techniques.

+ Proficient in mass spectrometry data analysis tools, specifically in-depth protein characterisation, MOA studies and pathway analysis packages.

+ Ability to manage teams of high functioning individuals and lead independent project teams.

+ Strong Interpersonal skills reflected in the ability to manage “up”, “down” and “across” in a matrix management organization

+ Effective time management, excellent technical communication skills, including scientific report writing and presentations

+ A collaborative approach to working cross functionally across research and development groups and commercial functions.

Applications must address the selection criteria above and include a current CV and covering letter.

Employment screening, including criminal history, medical assessment, confirmation of experience and stated qualifications, Australian working rights and other relevant checks form part of the candidate suitability evaluation process.

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CSL makes all employment decisions without regard to race, color, religion, national origin, ancestry, age, sex, gender, pregnancy, disability, marital status, sexual orientation, gender identity, genetic information, military status, protected veteran status (specifically status as a disabled veteran, recently separated veteran, armed forces service medal veteran, or active duty wartime or campaign badge veteran) or other classification protected by applicable US federal, state or local law. CSL complies with all applicable employment laws, including but not limited to Title VII of the Civil Rights Act of 1964, the Americans with Disabilities Act, the Fair Labor Standards Act, and the Immigration Reform and Control Act.